Ketamine for Neuropathic Pain

Ketamine is used to treat a variety of chronic pain syndromes, especially those with a neuropathic component. Neuropathic pain is a shooting, burning sensation that is usually caused by nerve damage or a malfunctioning nervous system. Antidepressant and anti-convulsive drugs are usually prescribed for the treatment of neuropathic pain and often do not provide a great deal of relief. Progressive symptoms from neuropathic pain also may lead to disabilities to co-morbid mood disorders.

Ketamine has been an effective treatment for pain since the early 1960s and is widely used in hospitals and ambulatory surgery centers for the treatment of pain during surgical procedures. Ketamine has the unique ability to not only block NMDA receptors, but it alters the way brain cells communicate by creating new pathways. This process of synaptogenesis or synaptic plasticity is believed to result in changes in the patient’s mood, anxiety, and response to pain.

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